Pub. Date : 2006 Sep
PMID : 16966095
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exit from arsenite-induced mitotic arrest is p53 dependent. | arsenite | tumor protein p53 | Homo sapiens |
| 2 | Using a model cell line in which p53 expression is regulated exogenously in a tetracycline-off system (TR9-7 cells) , our laboratory has shown that arsenite disrupts mitosis and that p53-deficient cells [p53(-)], in contrast to p53-expressing cells [p53(+)], display greater sensitivity to arsenite-induced mitotic arrest and apoptosis. | arsenite | tumor protein p53 | Homo sapiens |
| 3 | OBJECTIVE: Our goal was to examine the role p53 plays in protecting cells from arsenite-induced mitotic arrest. | arsenite | tumor protein p53 | Homo sapiens |
| 4 | RESULTS: Mitotic index analysis demonstrated that arsenite treatment delayed exit from G2 in p53(+) and p53(-) cells. | arsenite | tumor protein p53 | Homo sapiens |
| 5 | RESULTS: Mitotic index analysis demonstrated that arsenite treatment delayed exit from G2 in p53(+) and p53(-) cells. | arsenite | tumor protein p53 | Homo sapiens |
| 6 | Arsenite-treated p53(+) cells exited mitosis normally, whereas p53(-) cells exited mitosis with delayed kinetics. | arsenite | tumor protein p53 | Homo sapiens |
| 7 | Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells. | arsenite | tumor protein p53 | Homo sapiens |
| 8 | Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells. | arsenite | tumor protein p53 | Homo sapiens |
| 9 | Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells. | arsenite | tumor protein p53 | Homo sapiens |
| 10 | Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells. | arsenite | tumor protein p53 | Homo sapiens |
| 11 | CONCLUSIONS: p53 promotes mitotic exit and leads to more extensive ID1 induction by arsenite. | arsenite | tumor protein p53 | Homo sapiens |
| 12 | ID1 may play a role in the survival of arsenite-treated p53(+) cells and contribute to arsenic carcinogenicity. | arsenite | tumor protein p53 | Homo sapiens |