PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16966095-0	2006	Exit from arsenite-induced mitotic arrest is p53 dependent.	arsenite	10-18	tumor protein p53	Homo sapiens	45-48	
16966095-2	2006	Using a model cell line in which p53 expression is regulated exogenously in a tetracycline-off system (TR9-7 cells) , our laboratory has shown that arsenite disrupts mitosis and that p53-deficient cells [p53(-)], in contrast to p53-expressing cells [p53(+)], display greater sensitivity to arsenite-induced mitotic arrest and apoptosis.	arsenite	148-156	tumor protein p53	Homo sapiens	33-36	
16966095-3	2006	OBJECTIVE: Our goal was to examine the role p53 plays in protecting cells from arsenite-induced mitotic arrest.	arsenite	79-87	tumor protein p53	Homo sapiens	44-47	
16966095-5	2006	RESULTS: Mitotic index analysis demonstrated that arsenite treatment delayed exit from G2 in p53(+) and p53(-) cells.	arsenite	50-58	tumor protein p53	Homo sapiens	93-96	
16966095-5	2006	RESULTS: Mitotic index analysis demonstrated that arsenite treatment delayed exit from G2 in p53(+) and p53(-) cells.	arsenite	50-58	tumor protein p53	Homo sapiens	104-107	
16966095-6	2006	Arsenite-treated p53(+) cells exited mitosis normally, whereas p53(-) cells exited mitosis with delayed kinetics.	arsenite	0-8	tumor protein p53	Homo sapiens	17-20	
16966095-7	2006	Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells.	arsenite	59-67	tumor protein p53	Homo sapiens	201-204	
16966095-7	2006	Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells.	arsenite	59-67	tumor protein p53	Homo sapiens	212-215	
16966095-7	2006	Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells.	arsenite	133-141	tumor protein p53	Homo sapiens	201-204	
16966095-7	2006	Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells.	arsenite	133-141	tumor protein p53	Homo sapiens	212-215	
16966095-9	2006	CONCLUSIONS: p53 promotes mitotic exit and leads to more extensive ID1 induction by arsenite.	arsenite	84-92	tumor protein p53	Homo sapiens	13-16	
16966095-11	2006	ID1 may play a role in the survival of arsenite-treated p53(+) cells and contribute to arsenic carcinogenicity.	arsenite	39-47	tumor protein p53	Homo sapiens	56-59