Title : Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

Pub. Date : 2006 Sep

PMID : 16959615






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Oncogenic transformation of ovarian epithelial cells with H-Ras(V12) or expression of Bcr-Abl in hematopoietic cells causes elevated ROS generation and renders the malignant cells highly sensitive to PEITC, which effectively disables the glutathione antioxidant system and causes severe ROS accumulation preferentially in the transformed cells due to their active ROS output. Reactive Oxygen Species ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 Oncogenic transformation of ovarian epithelial cells with H-Ras(V12) or expression of Bcr-Abl in hematopoietic cells causes elevated ROS generation and renders the malignant cells highly sensitive to PEITC, which effectively disables the glutathione antioxidant system and causes severe ROS accumulation preferentially in the transformed cells due to their active ROS output. Reactive Oxygen Species ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
3 Oncogenic transformation of ovarian epithelial cells with H-Ras(V12) or expression of Bcr-Abl in hematopoietic cells causes elevated ROS generation and renders the malignant cells highly sensitive to PEITC, which effectively disables the glutathione antioxidant system and causes severe ROS accumulation preferentially in the transformed cells due to their active ROS output. Reactive Oxygen Species ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens