Title : Mitogen-activated protein kinase phosphatase-1 is required for cisplatin resistance.

Pub. Date : 2006 Sep 1

PMID : 16951204






2 Functional Relationships(s)
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1 Using primary mouse embryonic fibroblasts (MEF) from MKP-1 knockout mice, we show that induction of MKP-1 by cisplatin correlates with inactivation of c-Jun NH(2)-terminal kinase (JNK) but not ERK and p38. Cisplatin dual specificity phosphatase 1 Mus musculus
2 Using primary mouse embryonic fibroblasts (MEF) from MKP-1 knockout mice, we show that induction of MKP-1 by cisplatin correlates with inactivation of c-Jun NH(2)-terminal kinase (JNK) but not ERK and p38. Cisplatin dual specificity phosphatase 1 Mus musculus