Pub. Date : 2007 Feb
PMID : 16950602
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Epigallocatechin gallate (EGCG) mimics insulin action on the transcription factor FOXO1a and elicits cellular responses in the presence and absence of insulin. | epigallocatechin gallate | insulin | Homo sapiens |
| 2 | Epigallocatechin gallate (EGCG) mimics insulin action on the transcription factor FOXO1a and elicits cellular responses in the presence and absence of insulin. | epigallocatechin gallate | insulin | Homo sapiens |
| 3 | The green tea flavonoid epigallocatechin gallate (EGCG) is one of several compounds that have been reported to have insulin-like glucose-lowering properties in mammals. | epigallocatechin gallate | insulin | Homo sapiens |
| 4 | We show here that EGCG induces phosphorylation of insulin-sensitive residues on the transcription factor FOXO1a. | epigallocatechin gallate | insulin | Homo sapiens |
| 5 | Like insulin, EGCG induced FOXO1a phosphorylation is abolished by the PtdIns 3-kinase inhibitor LY294002 but not by PD98059 (an inhibitor of mitogen-activated protein kinase cascade) or by rapamycin (an inhibitor of signalling to p70 S6 kinase). | epigallocatechin gallate | insulin | Homo sapiens |
| 6 | These results indicate that EGCG exerts its insulin mimetic effects at least in part by phosphorylation of the FOXOs through a mechanism that is similar but not identical to insulin and IGF-1 induced FOXO phosphorylation. | epigallocatechin gallate | insulin | Homo sapiens |