Pub. Date : 1990 Jul 15
PMID : 1694852
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Monospecific antibody against purified rat liver cholesterol 7 alpha-hydroxylase cytochrome P-450 was used to screen a lambda gt11 cDNA library constructed from immuno-enriched polysomal RNA of cholestyramine-treated female rat liver. | Cholestyramine Resin | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |
| 2 | Cholesterol 7 alpha-hydroxylase mRNAs were induced 2- to 3-fold in rat liver by cholestyramine treatment. | Cholestyramine Resin | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |
| 3 | These experiments suggest that the induction of cholesterol 7 alpha-hydroxylase activity by cholestyramine or cholesterol and inhibition of cholesterol 7 alpha-hydroxylase activity by bile acid feedback are results of the rapid turnover of cholesterol 7 alpha-hydroxylase enzyme and mRNA levels. | Cholestyramine Resin | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |