Title : Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau.

Pub. Date : 2006 Jul 31

PMID : 16930454






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Fractionation of the mutant tau transfected cells revealed a significantly increased level of soluble tau in cytosol when wild-type PTEN was expressed, and an elevated level of SDS-soluble tau aggregates in the presence of the mutant PTEN. Sodium Dodecyl Sulfate phosphatase and tensin homolog Homo sapiens
2 In addition, the filter/trap assays detected more SDS-insoluble mutant tau aggregates in the cells overexpressing the mutant PTEN compared to those in the cells overexpressing wild-type PTEN and control DNA. Sodium Dodecyl Sulfate phosphatase and tensin homolog Homo sapiens