Title : Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.

Pub. Date : 2006 Aug

PMID : 16928811






1 Functional Relationships(s)
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1 Taken together, these results strongly suggest a model in which PEITC treatment of PC-3 cells activates ERK and JNK, which, in turn, phosphorylate Nrf2 and induce its translocation to the nucleus. phenethyl isothiocyanate NFE2 like bZIP transcription factor 2 Homo sapiens