Pub. Date : 2006 Oct
PMID : 16928443
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modulation of cell growth and cisplatin sensitivity by membrane gamma-glutamyltransferase in melanoma cells. | Cisplatin | gamma-glutamyltransferase light chain family member 3 | Homo sapiens |
| 2 | In addition, GGT-transfected cells exhibited reduced sensitivity to cisplatin associated with lower DNA platination. | Cisplatin | gamma-glutamyltransferase light chain family member 3 | Homo sapiens |
| 3 | In conclusion, these results indicate that GGT activity confers a growth advantage unrelated with intracellular glutathione supply, and are consistent with the interpretation that cisplatin resistance is the consequence of modifications of cellular pharmacokinetics as a result of extracellular drug inactivation by thiol metabolites originated by GGT-mediated GSH cleavage. | Cisplatin | gamma-glutamyltransferase light chain family member 3 | Homo sapiens |
| 4 | In conclusion, these results indicate that GGT activity confers a growth advantage unrelated with intracellular glutathione supply, and are consistent with the interpretation that cisplatin resistance is the consequence of modifications of cellular pharmacokinetics as a result of extracellular drug inactivation by thiol metabolites originated by GGT-mediated GSH cleavage. | Cisplatin | gamma-glutamyltransferase light chain family member 3 | Homo sapiens |