Title : A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.

Pub. Date : 2006 Nov

PMID : 16926278






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 All PDE5 constructs had similar affinities for 3-isobutyl-1-methylxanthine, sildenafil, tadalafil, and UK-122764, but mutants containing a complete GAF-B had 7- to 18-fold higher affinity for vardenafil-based compounds compared with those lacking a complete GAF-B. 1-Methyl-3-isobutylxanthine phosphodiesterase 5A Homo sapiens