Title : Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species.

Pub. Date : 2006 Sep 28

PMID : 16919261






3 Functional Relationships(s)
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1 The objectives of the present study were to determine the effects of azelnidipine, a new calcium channel blocker, on the expression of VCAM-1 induced by 7-ketocholesterol, components of ox-LDL, and tumor necrosis factor-alpha (TNF-alpha). 7-ketocholesterol vascular cell adhesion molecule 1 Homo sapiens
2 The surface expression and mRNA levels of VCAM-1 were determined by enzyme immunoassay and RT-PCR performed on endothelial cell monolayers stimulated with 7-ketocholesterol or TNF-alpha. 7-ketocholesterol vascular cell adhesion molecule 1 Homo sapiens
3 These results suggest that azelnidipine works as an anti-atherogenic agent by inhibiting the reactive oxygen species-dependent expression of VCAM-1 induced by 7-ketocholesterol and TNF-alpha. 7-ketocholesterol vascular cell adhesion molecule 1 Homo sapiens