Title : Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, the major autoantigen of primary biliary cirrhosis. Implication for a conformational autoepitope.

Pub. Date : 1990 May 1

PMID : 1691756






2 Functional Relationships(s)
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1 Previous work, using only a partial length rat liver cDNA clone of PDH-E2, demonstrated that the immunodominant epitope was localized to the lipoic acid binding site. Thioctic Acid pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens
2 Human PDH-E2, in contrast to rat PDH-E2, has two lipoic acid binding sites. Thioctic Acid pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens