Title : Hypoxia enhances lysophosphatidic acid responsiveness in ovarian cancer cells and lysophosphatidic acid induces ovarian tumor metastasis in vivo.

Pub. Date : 2006 Aug 15

PMID : 16912173






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 LPA-induced cell migration required cytosolic phospholipase A(2) (cPLA(2)) and LPA stimulates cPLA(2) phosphorylation in a HIF1 alpha-dependent manner under hypoxia conditions. lysophosphatidic acid hypoxia inducible factor 1 subunit alpha Homo sapiens
2 LPA-induced cell migration required cytosolic phospholipase A(2) (cPLA(2)) and LPA stimulates cPLA(2) phosphorylation in a HIF1 alpha-dependent manner under hypoxia conditions. lysophosphatidic acid hypoxia inducible factor 1 subunit alpha Homo sapiens
3 HIF1 alpha plays a critical role in enhancing and/or sensitizing the role of LPA on cell migration and invasion under hypoxic conditions, where cPLA(2) is required for LPA-induced cell migration. lysophosphatidic acid hypoxia inducible factor 1 subunit alpha Homo sapiens
4 HIF1 alpha plays a critical role in enhancing and/or sensitizing the role of LPA on cell migration and invasion under hypoxic conditions, where cPLA(2) is required for LPA-induced cell migration. lysophosphatidic acid hypoxia inducible factor 1 subunit alpha Homo sapiens