Title : Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity.

Pub. Date : 2006 Oct 13

PMID : 16912036






1 Functional Relationships(s)
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1 Substitution of the SH3-SH2 tyrosine phosphorylation sites with phenylalanine substantially reduced Bcr-Abl-mediated transformation of TF-1 myeloid cells to cytokine independence. Phenylalanine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens