Pub. Date : 2006 Aug
PMID : 16908950
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAF1). | trichostatin A | KRAS proto-oncogene, GTPase | Rattus norvegicus |
| 2 | TSA treatment also induced the expression of p21(WAF1) but not of p16(INK4), p27(KIP1) or p53. | trichostatin A | KRAS proto-oncogene, GTPase | Rattus norvegicus |
| 3 | In conclusion, TSA inhibits VSMC proliferation via the induction of p21(WAF1) expression and subsequent cell-cycle arrest with reduction of the phosphorylation of Rb protein at the G1-S phase. | trichostatin A | KRAS proto-oncogene, GTPase | Rattus norvegicus |