Title : Protection against MDMA-induced dopaminergic neurotoxicity in mice by methyllycaconitine: involvement of nicotinic receptors.

Pub. Date : 2006 Sep

PMID : 16901518






2 Functional Relationships(s)
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1 In vivo, methyllycaconitine (MLA), a specific alpha-7 nAChR antagonist, significantly prevented MDMA-induced neurotoxicity at dopaminergic but not at serotonergic level, without affecting MDMA-induced hyperthermia. methyllycaconitine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 In vivo, methyllycaconitine (MLA), a specific alpha-7 nAChR antagonist, significantly prevented MDMA-induced neurotoxicity at dopaminergic but not at serotonergic level, without affecting MDMA-induced hyperthermia. methyllycaconitine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus