Pub. Date : 2006 Oct 10
PMID : 16891067
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The induction of CYP1A1 expression by oltipraz, a synthetic chemo-preventive agent, which increases intracellular calcium concentration, has previously been shown to result from transcriptional activation of CYP1A1 gene mediated by the Ah receptor (AhR), although oltipraz does not bind the receptor. | Calcium | aryl hydrocarbon receptor | Homo sapiens |
| 2 | The presented data established for the first time a mechanism of activating AhR and its transcription of CYP1A1 by oltipraz through activation of calcium-dependent calpain. | Calcium | aryl hydrocarbon receptor | Homo sapiens |