Title : Human CD4+ T lymphocytes with increased intracellular cAMP levels exert regulatory functions by releasing extracellular cAMP.

Pub. Date : 2006 Oct

PMID : 16888088






4 Functional Relationships(s)
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1 Human CD4+ T lymphocytes with increased intracellular cAMP levels exert regulatory functions by releasing extracellular cAMP. Cyclic AMP CD4 molecule Homo sapiens
2 Human CD4+ T lymphocytes with increased intracellular cAMP levels exert regulatory functions by releasing extracellular cAMP. Cyclic AMP CD4 molecule Homo sapiens
3 It is interesting that this phenomenon was not mediated by inhibitory cytokines such as IL-10, IL-4, or TGF-beta but was in part caused by the release of extracellular cAMP by the CD4(+) T lymphocytes. Cyclic AMP CD4 molecule Homo sapiens
4 Our results show that CD4(+) T lymphocytes can exert regulatory functions through the release of extracellular cAMP and that the cyclic nucleotide acts as a primary messenger, which could play a biological role in the modulation of immune responses. Cyclic AMP CD4 molecule Homo sapiens