Title : Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1.

Pub. Date : 2006 Nov

PMID : 16887917






2 Functional Relationships(s)
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1 In the present study, our aim was to identify endogenous ligands for SF1 and characterize their functional significance in mediating cAMP-dependent transcription of human CYP17. Cyclic AMP cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 SPH antagonized the ability of cAMP and the coactivator steroid receptor coactivator-1 to increase CYP17 reporter gene activity. Cyclic AMP cytochrome P450 family 17 subfamily A member 1 Homo sapiens