Title : Glucocorticoid up-regulates transforming growth factor-beta (TGF-beta) type II receptor and enhances TGF-beta signaling in human prostate cancer PC-3 cells.

Pub. Date : 2006 Nov

PMID : 16887915






1 Functional Relationships(s)
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1 Dex also enhanced TGF-beta1 signaling and increased the expression of cyclin-dependent kinase inhibitors p15(INK4B) (p15) and p27(KIP1) (p27), which are the target genes of TGF-beta1 and have been identified as inducers of cell cycle arrest at the G1 checkpoint. Dexamethasone cyclin dependent kinase inhibitor 1B Homo sapiens