Title : Activation of common antiviral pathways can potentiate inflammatory responses to septic shock.

Pub. Date : 2006 Aug

PMID : 16878028






2 Functional Relationships(s)
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1 To assess the NF-kappaB contribution to PIC-modulated inflammatory responses to septic shock, we treated with parthenolide, an NF-kappaB inhibitor before PIC and septic shock. parthenolide nuclear factor kappa B subunit 1 Homo sapiens
2 Inhibition of NF-kappaB by parthenolide did reduce IFN-alpha-mediated potentiation of the cytokine response and lethality from septic shock. parthenolide nuclear factor kappa B subunit 1 Homo sapiens