Title : Comparative study between Hfe-/- and beta2m-/- mice: progression with age of iron status and liver pathology.

Pub. Date : 2006 Aug

PMID : 16875497






5 Functional Relationships(s)
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1 The purpose of this study was to compare development of iron load in of beta2m-/- and Hfe-/- mice paying special attention to liver pathology in older age groups. Iron beta-2 microglobulin Mus musculus
2 Liver iron content of beta2m-/-, Hfe-/- and control B6 mice of different ages (varying from 3 weeks to 18 months) was examined. Iron beta-2 microglobulin Mus musculus
3 The beta2m-/- strain presents higher hepatic iron content, hepatocyte nuclear iron inclusions, mitochondria abnormalities. Iron beta-2 microglobulin Mus musculus
4 The beta2m-/- strain presents higher hepatic iron content, hepatocyte nuclear iron inclusions, mitochondria abnormalities. Iron beta-2 microglobulin Mus musculus
5 The steatosis commonly observed the beta2m-/- mice may be a reflection of its higher hepatic iron content. Iron beta-2 microglobulin Mus musculus