Title : Differential effects of Ca2+ and cAMP on transcription mediated by MEF2D and cAMP-response element-binding protein in hippocampal neurons.

Pub. Date : 2006 Sep 22

PMID : 16870618






2 Functional Relationships(s)
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1 We have also shown that cAMP inhibits Ca(2+)-induced nuclear export of the MEF2 co-repressor HDAC5 and prevents Ca(2+)-stimulated nuclear import of the MEF2 co-activator NFAT3/c4. Cyclic AMP histone deacetylase 5 Homo sapiens
2 Our results suggest that cAMP interferes with MEF2D-mediated gene expression at multiple levels by antagonizing the derepression of MEF2D by HDAC5 and by inhibiting recruitment of the co-activator NFAT. Cyclic AMP histone deacetylase 5 Homo sapiens