Title : Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae.

Pub. Date : 2006 Sep 29

PMID : 16864574






3 Functional Relationships(s)
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1 In cells using ammonium or glutamine, the GATA transcription factor Gln3 is sequestered in the cytoplasm by Ure2 whereas it enters the nucleus after a shift to a nonpreferred nitrogen source like proline or upon addition of rapamycin, the TOR complex inhibitor. Ammonium Compounds nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C
2 The derepression of Gln3-activated genes in ammonium-grown npr1 cells results from the reduced uptake of the nitrogen-repressing compound because NCR could be restored in npr1 cells by repairing ammonium-uptake defects through different means. Ammonium Compounds nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C
3 The derepression of Gln3-activated genes in ammonium-grown npr1 cells results from the reduced uptake of the nitrogen-repressing compound because NCR could be restored in npr1 cells by repairing ammonium-uptake defects through different means. Ammonium Compounds nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C