Pub. Date : 2006 Feb
PMID : 16863464
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Contribution of CYP2C9 to variability in vitamin K antagonist metabolism. | Vitamin K | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | CYP2C9 makes a very important contribution to metabolism of vitamin K antagonist anticoagulants, and is the main oxidising enzyme for S-warfarin and S-acenocoumarol as well as contributing to phenprocoumon metabolism. | Vitamin K | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | Although CYP2C9 genotype is clearly a predictor of vitamin K antagonist dose requirement, especially in Caucasian populations in whom variant alleles are common, a number of recent studies have shown that age, genotype for the gene encoding the target gene vitamin K epoxide reductase and concomitant drugs are equally important factors in determining dose. | Vitamin K | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |