Title : Developmental and tissue-specific involvement of peroxisome proliferator-activated receptor-alpha in the control of mouse uncoupling protein-3 gene expression.

Pub. Date : 2006 Oct

PMID : 16857752






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Fatty acids are powerful regulators of UCP3 gene transcription. Fatty Acids uncoupling protein 3 (mitochondrial, proton carrier) Mus musculus
2 The murine UCP3 promoter is activated by fatty acids through either PPARalpha or PPARdelta but not by PPARgamma or retinoid X receptor alone. Fatty Acids uncoupling protein 3 (mitochondrial, proton carrier) Mus musculus
3 Thus, PPARalpha-dependent regulation is required for appropriate gene regulation of UCP3 as part of the subset of fatty-acid-responsive genes in neonatal muscle and heart. Fatty Acids uncoupling protein 3 (mitochondrial, proton carrier) Mus musculus