Title : Characterization of the cytochrome P450 enzymes involved in the metabolism of a new cardioprotective agent KR-33028.

Pub. Date : 2006 Oct 10

PMID : 16857327






1 Functional Relationships(s)
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1 Correlation analysis between the known CYP enzyme activities and the rates of the formation of 5-hydroxy- and 7-hydroxy-KR-33028 in the 16 human liver microsomes has showed significant correlations with CYP3A4-mediated midazolam 1"-hydroxylation and CYP1A2-mediated phenacetin O-deethylation, respectively. Midazolam cytochrome P450 family 4 subfamily F member 3 Homo sapiens