Title : Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase and nuclear factor kappa B activation in rat skeletal muscle.

Pub. Date : 2006 Aug

PMID : 16842535






3 Functional Relationships(s)
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1 This study investigated whether the induction of inducible nitric oxide synthase (iNOS) produced by acute exercise in rat skeletal muscle could be prevented by melatonin and whether iNOS down-regulation was related to inhibition of nuclear factor kappaB (NF-kappaB) activation. Melatonin nitric oxide synthase 2 Rattus norvegicus
2 Exercise caused a significant induction of iNOS protein levels and a marked activation of NF-kappaB that were significantly prevented in rats treated with melatonin. Melatonin nitric oxide synthase 2 Rattus norvegicus
3 Our data indicate that melatonin has potent protective effects against damage caused by acute exercise in rat muscle, preventing oxidative stress, NF-kappaB activation and iNOS over-expression. Melatonin nitric oxide synthase 2 Rattus norvegicus