Pub. Date : 2006 Oct
PMID : 16837625
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation. | Methadone | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 2 | Thus, hPXR activation in vivo increased P-glycoprotein activity and tightened the blood-brain barrier to methadone, reducing the drug"s CNS efficacy. | Methadone | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |