Title : Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.

Pub. Date : 2006 Sep 1

PMID : 16831409






1 Functional Relationships(s)
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1 OBJECTIVE: N, N-Dimethylsphingosine (DMS) is recognized as an inhibitor of sphingosine kinase (SphK), a key enzyme responsible for the formation of sphingosine-1-phosphate (S1P). N,N-dimethylsphingosine sphingosine-1-phosphate receptor 1 Mus musculus