Title : The mechanisms of Ara-C-induced apoptosis of resting B-chronic lymphocytic leukemia cells.

Pub. Date : 2006 Jul

PMID : 16818278






1 Functional Relationships(s)
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1 INTERPRETATION AND CONCLUSIONS: In conclusion, our data indicate that Ara-C can induce apoptosis in resting G(O)-B-CLL cells using a mechanism independent of cell proliferation and DNA replication but associated with inhibition of RNA synthesis and downregulation of Mcl-1. Cytarabine MCL1 apoptosis regulator, BCL2 family member Homo sapiens