Pub. Date : 2006 Sep
PMID : 16806295
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic DHEAS administration facilitates hippocampal long-term potentiation via an amplification of Src-dependent NMDA receptor signaling. | Dehydroepiandrosterone Sulfate | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 2 | Here we report that the sub-threshold HFS could trigger the phosphorylation of Src and ERK2 in the DHEAS-treated rats, but not in control rats. | Dehydroepiandrosterone Sulfate | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 3 | We found in slices obtained from the DHEAS-treated rats that NMDA-induced intracellular Ca2+([Ca2+]i) transients in CA1 pyramidal neurons were significantly potentiated, which was essential for the Src and ERK2 phosphorylations. | Dehydroepiandrosterone Sulfate | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 4 | The activation of ERK2, a downstream factor of Src family kinase, was required for the DHEAS-facilitated LTP. | Dehydroepiandrosterone Sulfate | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 5 | The Src family kinase inhibitor PP2, but not its inactive homologue PP3, attenuated the NMDA-induced [Ca2+]i increase and abolished the DHEAS-facilitated LTP. | Dehydroepiandrosterone Sulfate | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 6 | This novel postsynaptic NMDAr/Src-mediated signal amplification through "NMDAr-Ca2+-->Src-->NMDAr-Ca2+" cycle may play a pivotal role in the DHEAS-facilitated LTP induction. | Dehydroepiandrosterone Sulfate | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 7 | This novel postsynaptic NMDAr/Src-mediated signal amplification through "NMDAr-Ca2+-->Src-->NMDAr-Ca2+" cycle may play a pivotal role in the DHEAS-facilitated LTP induction. | Dehydroepiandrosterone Sulfate | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |