PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16806295-0 2006 Chronic DHEAS administration facilitates hippocampal long-term potentiation via an amplification of Src-dependent NMDA receptor signaling. Dehydroepiandrosterone Sulfate 8-13 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 100-103 16806295-3 2006 Here we report that the sub-threshold HFS could trigger the phosphorylation of Src and ERK2 in the DHEAS-treated rats, but not in control rats. Dehydroepiandrosterone Sulfate 99-104 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 79-82 16806295-4 2006 We found in slices obtained from the DHEAS-treated rats that NMDA-induced intracellular Ca2+([Ca2+]i) transients in CA1 pyramidal neurons were significantly potentiated, which was essential for the Src and ERK2 phosphorylations. Dehydroepiandrosterone Sulfate 37-42 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 198-201 16806295-5 2006 The activation of ERK2, a downstream factor of Src family kinase, was required for the DHEAS-facilitated LTP. Dehydroepiandrosterone Sulfate 87-92 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 47-50 16806295-6 2006 The Src family kinase inhibitor PP2, but not its inactive homologue PP3, attenuated the NMDA-induced [Ca2+]i increase and abolished the DHEAS-facilitated LTP. Dehydroepiandrosterone Sulfate 136-141 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 4-7 16806295-9 2006 This novel postsynaptic NMDAr/Src-mediated signal amplification through "NMDAr-Ca2+-->Src-->NMDAr-Ca2+" cycle may play a pivotal role in the DHEAS-facilitated LTP induction. Dehydroepiandrosterone Sulfate 147-152 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 30-33 16806295-9 2006 This novel postsynaptic NMDAr/Src-mediated signal amplification through "NMDAr-Ca2+-->Src-->NMDAr-Ca2+" cycle may play a pivotal role in the DHEAS-facilitated LTP induction. Dehydroepiandrosterone Sulfate 147-152 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 89-92