Title : Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation.

Pub. Date : 2006 Aug 7

PMID : 16806165






4 Functional Relationships(s)
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1 Glutamate exposure also induced a transient increase in caspase-3 activity. Glutamic Acid caspase 3 Homo sapiens
2 A membrane-permeable inhibitor of caspase-3 (DEVD-CHO) prevented the glutamate neurotoxicity. Glutamic Acid caspase 3 Homo sapiens
3 Moreover, serofendic acid reduced the activation of caspase-3 induced by glutamate. Glutamic Acid caspase 3 Homo sapiens
4 These results indicate that serofendic acid prevents glutamate-induced apoptosis in cultured cortical neurons by the prevention of loss of mitochondrial membrane potential and the reduction of the process of caspase-3 activation. Glutamic Acid caspase 3 Homo sapiens