PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16806165-4 2006 Glutamate exposure also induced a transient increase in caspase-3 activity. Glutamic Acid 0-9 caspase 3 Homo sapiens 56-65 16806165-5 2006 A membrane-permeable inhibitor of caspase-3 (DEVD-CHO) prevented the glutamate neurotoxicity. Glutamic Acid 69-78 caspase 3 Homo sapiens 34-43 16806165-12 2006 Moreover, serofendic acid reduced the activation of caspase-3 induced by glutamate. Glutamic Acid 73-82 caspase 3 Homo sapiens 52-61 16806165-14 2006 These results indicate that serofendic acid prevents glutamate-induced apoptosis in cultured cortical neurons by the prevention of loss of mitochondrial membrane potential and the reduction of the process of caspase-3 activation. Glutamic Acid 53-62 caspase 3 Homo sapiens 208-217