Pub. Date : 2006 Aug 7
PMID : 16797122
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice. | Cocaine | aquaporin 4 | Mus musculus |
| 2 | The results reveal that AQP4 deletion attenuated locomotor activity in acute and repeated cocaine exposure mice, and induced a decrease of extracellular dopamine and glutamate levels in the nucleus accumbens (NAc), a brain region known to be critically involved in the addictive properties of cocaine. | Cocaine | aquaporin 4 | Mus musculus |
| 3 | The results reveal that AQP4 deletion attenuated locomotor activity in acute and repeated cocaine exposure mice, and induced a decrease of extracellular dopamine and glutamate levels in the nucleus accumbens (NAc), a brain region known to be critically involved in the addictive properties of cocaine. | Cocaine | aquaporin 4 | Mus musculus |
| 4 | Therefore, AQP4 may play a role in regulating extracellular cocaine-induced dopamine and glutamate release in the brain reward center, and in turn AQP4 deletion may attenuate cocaine reinforcement and dependence. | Cocaine | aquaporin 4 | Mus musculus |