Pub. Date : 2006 Aug 14
PMID : 16782270
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of treatment with acamprosate on beta-endorphin plasma concentration in humans with high alcohol preference. | Alcohols | proopiomelanocortin | Homo sapiens |
| 2 | Treatment with acamprosate, a compound used for relapse prevention treatment of alcoholism, was recently shown to be associated with increased plasma concentration of beta-endorphin in rats selectively bred for high alcohol preference. | Alcohols | proopiomelanocortin | Homo sapiens |
| 3 | Since beta-endorphin deficiency was earlier associated with alcohol craving and anxiety during withdrawal, abstinence maintaining effects of acamprosate might at least be partially related with the ability to modulate opioidergic activity especially in the subsample of HP patients with an attenuated opioidergic activity during this state. | Alcohols | proopiomelanocortin | Homo sapiens |