Title : Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid.

Pub. Date : 2007 Apr

PMID : 16781858






3 Functional Relationships(s)
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1 Pretreatment with 100 microM EPA and DHA significantly decreased lipopolysaccharide (LPS)-stimulated THP-1 macrophage tumor necrosis factor (TNF) alpha, interleukin (IL) 1beta and IL-6 production (P<.02), compared to control cells. Docosahexaenoic Acids interleukin 1 beta Homo sapiens
2 Both EPA and DHA reduced TNF-alpha, IL-1beta and IL-6 mRNA expression. Docosahexaenoic Acids interleukin 1 beta Homo sapiens
3 Furthermore, a low dose (25 microM) of DHA had a greater inhibitory effect than that of EPA on macrophage IL-1beta (P<.01 and P<.04, respectively) and IL-6 (P<.003 and P<.003, respectively) production following 0.01 and 0.1 microg/ml LPS stimulation. Docosahexaenoic Acids interleukin 1 beta Homo sapiens