Pub. Date : 2006 Jun 14
PMID : 16775132
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, the roles of D1 receptors, CREB, and GluR1 in morphine dependence are not well understood. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 2 | Surprisingly, SKF 82958 increased P-GluR1, but not P-CREB, in the NAc, and naloxone reduced SKF 82958-mediated P-GluR1 induction specifically in morphine-dependent rats. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |
| 3 | These data raise the possibility that the rewarding effects of SKF 82958 in morphine-dependent rats involve increased P-GluR1 in the NAc, although the involvement of other brain regions cannot be ruled out. | Morphine | glutamate ionotropic receptor AMPA type subunit 1 | Rattus norvegicus |