Title : LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells.

Pub. Date : 2006 Jul

PMID : 16773206






3 Functional Relationships(s)
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1 LY294002 suppressed the heat-induced accumulation of heat shock protein 27 (hsp27) and heat shock protein 72 (hsp72) in these cell lines. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one heat shock protein family A (Hsp70) member 1A Homo sapiens
2 LY294002 suppressed the heat-induced accumulation of heat shock protein 27 (hsp27) and heat shock protein 72 (hsp72) in these cell lines. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one heat shock protein family A (Hsp70) member 1A Homo sapiens
3 These results suggest that LY294002 inhibits anti-apoptosis signaling through hsp27 and hsp72 as well as cell survival signaling through Akt and survivin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one heat shock protein family A (Hsp70) member 1A Homo sapiens