Title : Staurosporine-induced growth inhibition of glioma cells is accompanied by altered expression of cyclins, CDKs and CDK inhibitors.

Pub. Date : 2006 May

PMID : 16770740






3 Functional Relationships(s)
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1 The levels of CDK2, CDC2, Cyclin A and Cyclin B proteins decreased, while the levels of CDK inhibitors viz., p21 and p27 were found to increase on staurosporine treatment. Staurosporine cyclin dependent kinase 2 Homo sapiens
2 The mRNA levels of CDK2 and CDC2 genes were also found to decrease on staurosporine treatment. Staurosporine cyclin dependent kinase 2 Homo sapiens
3 Thus apart from staurosporine"s known direct inhibitory effect on CDK2 and CDC2 activities, staurosporine was found to down-regulate activities of these two kinases by modulating the expression of the kinases themselves as well that of their activating partners (Cyclins) and their inhibitors. Staurosporine cyclin dependent kinase 2 Homo sapiens