Pub. Date : 2006 May
PMID : 16770740
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The levels of CDK2, CDC2, Cyclin A and Cyclin B proteins decreased, while the levels of CDK inhibitors viz., p21 and p27 were found to increase on staurosporine treatment. | Staurosporine | cyclin dependent kinase 2 | Homo sapiens |
2 | The mRNA levels of CDK2 and CDC2 genes were also found to decrease on staurosporine treatment. | Staurosporine | cyclin dependent kinase 2 | Homo sapiens |
3 | Thus apart from staurosporine"s known direct inhibitory effect on CDK2 and CDC2 activities, staurosporine was found to down-regulate activities of these two kinases by modulating the expression of the kinases themselves as well that of their activating partners (Cyclins) and their inhibitors. | Staurosporine | cyclin dependent kinase 2 | Homo sapiens |