Title : beta-Secretase inhibitors: modification at the P4 position and improvement of inhibitory activity in cultured cells.

Pub. Date : 2006 Aug 15

PMID : 16757166






2 Functional Relationships(s)
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1 Recently, we reported potent and small-sized beta-secretase (BACE1) inhibitors KMI-570 and KMI-684 in which we replaced carboxylic acid groups at the P(1)(") position of KMI-420 and KMI-429, respectively, with tetrazole derivatives as carboxylic acid bioisosteres. Carboxylic Acids beta-secretase 1 Homo sapiens
2 Recently, we reported potent and small-sized beta-secretase (BACE1) inhibitors KMI-570 and KMI-684 in which we replaced carboxylic acid groups at the P(1)(") position of KMI-420 and KMI-429, respectively, with tetrazole derivatives as carboxylic acid bioisosteres. Carboxylic Acids beta-secretase 1 Homo sapiens