Title : Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation.

Pub. Date : 2006 Sep 1

PMID : 16751250






2 Functional Relationships(s)
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1 We develop a model of tyrosine phosphorylation and activation of the T-cell receptor (TCR) by localization to regions of close membrane-membrane proximity (close contact) that physically exclude tyrosine phosphatases such as CD45. Tyrosine T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens
2 We develop a model of tyrosine phosphorylation and activation of the T-cell receptor (TCR) by localization to regions of close membrane-membrane proximity (close contact) that physically exclude tyrosine phosphatases such as CD45. Tyrosine T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens