Pub. Date : 2006 Jun
PMID : 16741004
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic high-sodium diet increases aortic wall endothelin-1 expression in a blood pressure-independent fashion in rats. | Sodium | endothelin 1 | Rattus norvegicus |
| 2 | We hypothesized that a high-sodium diet (HNa) increases vascular ET-1 production independent of arterial blood pressure changes. | Sodium | endothelin 1 | Rattus norvegicus |
| 3 | Comparing WKY rats fed a low-sodium diet (LNa) with those fed HNa for 3 weeks, aortic wall ET-1 protein is significantly increased in response to HNa (331 +/- 43 pg/g tissue for LNa vs. 557 +/- 34 pg/gm tissue for HNa). | Sodium | endothelin 1 | Rattus norvegicus |
| 4 | Therefore, the expression of ET-1 mRNA by the aortic wall is increased in response to chronic high dietary sodium in WKY rats in the absence of changes in arterial blood pressure. | Sodium | endothelin 1 | Rattus norvegicus |