Title : Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor.

Pub. Date : 2006 Jun 1

PMID : 16740780






1 Functional Relationships(s)
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1 Addition of imatinib to ADW742 synergistically augmented these effects and was especially effective in inhibiting AKT/mTOR phosphorylation and reducing vascular endothelial growth factor expression in cell lines having high IGF1R activation levels. Imatinib Mesylate mechanistic target of rapamycin kinase Homo sapiens