Pub. Date : 2006 Aug 1
PMID : 16739166
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Film autoradiographic studies showed that nicotine significantly increased c-fos mRNA expression in both PVN and CEA. | Nicotine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | Pretreatment with the centrally acting nicotinic antagonist, mecamylamine (1 mg/kg), blocked nicotine"s effects, whereas pretreatment with the peripherally acting antagonist, hexamethonium (5 mg/kg), did not, indicating that c-fos induction was mediated by a central nicotinic receptor. | Nicotine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | Double labeling studies showed that nicotine induced c-fos expression within CRF cells in the PVN, as well as in a small population of ENK cells, but not in PVN DYN cells. | Nicotine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 4 | In contrast, there was no significant nicotine-induced increase in c-fos expression in CEA CRF or DYN cells, whereas nicotine treatment did increase c-fos expression within CEA ENK cells. | Nicotine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |