Title : [Effect of sulfasalazine and its metabolites on prostaglandin and leukotriene liberation from human synovial tissue].

Pub. Date : 1991

PMID : 1673814






3 Functional Relationships(s)
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Protein Name
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1 The effective concentrations of SASP and SP were found to be in the range which can be reached during SASP therapy. Sulfapyridine aspartic peptidase retroviral like 1 Homo sapiens
2 While nonsteroidal anti-inflammatory drugs, which are used for symptomatic therapy of rheumatoid arthritis, inhibit cyclooxygenase only, SP, the active metabolite of the second line anti-rheumatic drug SASP, inhibits both PG and LT release. Sulfapyridine aspartic peptidase retroviral like 1 Homo sapiens
3 Inhibition of LT synthesis by SASP and SP could contribute to the second line efficacy of SASP therapy in rheumatoid arthritis. Sulfapyridine aspartic peptidase retroviral like 1 Homo sapiens