Pub. Date : 2006 Jul
PMID : 16733806
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bortezomib induces in HepG2 cells IkappaBalpha degradation mediated by caspase-8. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |
| 2 | The present paper demonstrates that the proteasome inhibitor bortezomib, which behaves as an apoptotic agent in hepatoma HepG2 cells, caused in these cells a decrease in IkappaBalpha level and a consequent increase in NF-kappaB activity. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |
| 3 | The effect already appeared at 4 h of treatment and preceded the onset of apoptosis which was observed at 24 h. Our results demonstrate that bortezomib-induced IkappaBalpha degradation occurred in conjunction with the activation of caspase-8; moreover, the decrease in IkappaBalpha level was prevented in a dose-dependent manner by the addition of z-IETD, a specific inhibitor of caspase-8. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |
| 4 | The effect already appeared at 4 h of treatment and preceded the onset of apoptosis which was observed at 24 h. Our results demonstrate that bortezomib-induced IkappaBalpha degradation occurred in conjunction with the activation of caspase-8; moreover, the decrease in IkappaBalpha level was prevented in a dose-dependent manner by the addition of z-IETD, a specific inhibitor of caspase-8. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |