Title : Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis.

Pub. Date : 2006 Jul

PMID : 16729291






1 Functional Relationships(s)
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1 RESULTS: We demonstrate that lovastatin and simvastatin induce a 50 to 60% reduction in the diffusion rates of bovine serum albumin and [(14)C]-sucrose across human BBB-ECs in vitro through abrogation of isoprenylation processes, but independent of the expression of the tight junction molecules occludin, VE-cadherin, JAM-1, zonula occluden-1, and zonula occluden-2. Lovastatin cadherin 5 Homo sapiens