Pub. Date : 1991 Mar
PMID : 1672380
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High efficacy 5-HT1A agonists attenuate morphine-induced antinociception in mice in a competitive-like manner. | Morphine | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 2 | The selective 5-HT1A agonist, (+-)-8-hydroxy-diprolaminotetralin HBr (8-OH-DPAT), dose-dependently antagonized morphine-induced antinociception (MIA) without affecting the latency to respond when applied alone. | Morphine | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 3 | These data show that, over a certain range of doses, the systemic administration of 8-OH-DPAT and other high efficacy 5-HT1A agonists functionally antagonizes the antinociceptive action of systemically applied morphine in a competitive-like manner. | Morphine | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |